Influence of Acute Workouts on the BDNF Levels in Hippocampus-exposed Rats
Document Type : Original Article
Abstract
Purpose: It was shown that with acute low-intensity exercise that is minimally stressful, hippocampus activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield greater benefits in hippocampus functions compared to the more strenuous forms. The neuroprotective effects of acute workout training on lead acetate-induced BDNF levels were investigated. Material and Methods: Thirty -two adult, male, Wistar rats were randomly classified into 4 groups; Rats were randomly assigned to 1) basic group (Base-B, n = 10), 2) control group (lead-L, n=10) 3), lead injection group (acute pre, n=10) and 4) treadmill exercise with lead injection group (acute post, n=10). The rats in groups 3 and 4 experienced the treadmill running 15 to 22m/min, 25 to 64minutes, 5 times a week, and for 8 weeks. Groups 3 and 4 received lead acetate (20 mg/kg) and the sham group received solvent (ethyl oleat). Results: The results showed that BDNF in Lead acetate group decreased significantly whereas it increased in Lead acetate + Workout group. Obtained data suggest a lifestyle-induced protective potential in rehabilitation of lead-induced neurodegeneration. Discussion and Conclusion: findings from the present research indicated the significant role of exercises in improving BDNF level. Increased level of BDNF may act as neuroprotector in recovery from numerous disturbances, such as reduction of the brain weight, memory loss and different degenerative processes. It may be concluded that the increase of BDNF in hippocampus may cause positive plastic changes and prevent the mentioned disturbance
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