Effects of Aerobic Training, with or without Zizyphus Jujuba Water Extraction, on Fundus Nesfatin-1, ATP, HDL-C, and LDL-C Concentrations in Female Rats

Document Type : Original Article

Abstract

Purpose: The aim of this study was to investigate the effects of six weeks of aerobic training, with and 
without extract of Jujuba, on fundus nesfatin-1, ATP concentration, plasma High-density lipoprotein (HDL), 
and Low-density lipoprotein (LDL) levels in female rats.
Material and Methods: 28 Wistar rats were randomly assigned to Saline-control, Saline-training, Jujubacontrol and Jujuba-training groups. Training groups were given exercise on a motor-driven treadmill at 35 
m/min (0% grade) for 60 min/day and 5 days/week for six weeks. Animals were fed orally, with Jujuba 
extraction and Saline (3 weeks, 60 mg per 100 g body weight). 72 hours after the last training session and after 
four hours of fasting, the rats were sacrificed, and their fundus tissue was excised. Some plasma was also 
collected for plasma variable measurements. All variables were compared using one way analyzes of variances. 
Correlations were calculated using the Pearson Product Moment correlation. All P values <0.05 were 
considered as significant.
Results: nesfatin-1 significantly increased in saline training group compared to saline control group 
(P<0.028). Exercise training (P<0.091) and extraction (P<0.031) independently increased plasma HDL-C and 
decreased fundus ATP (P<0.002). There was no significant difference between groups regarding plasma LDL 
concentration. There was also no correlation between fundus nesfatin-1 concentration and plasma HDL, LDL 
and fundus ATP.
Discussion and Conclusion: Exercise and using Jujuba extraction may prevent over-weight and 
cardiovascular diseases.

Keywords

• Aerobic training
• Nesfatin-1
• Female rat
• Zizyphus jujuba water extraction

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