ABCG1 Gene Responses to Treadmill Running with or without Pistachio-Atlantica in Female Rats

Document Type : Original Article

Abstract

Intrudaction: ABCG1 is the first member of the ABCG subfamily. The protein is expressed in many cell 
types and in numerous tissues including the kidney, lung, liver, and intestine. The aim of this study was to 
determine the small intestine and kidney ABCG1 relative gene expression in response to treadmill-running 
training in female rats.
Material and Methods: Twenty Wistar rats (6-8 weeks old and 125-135 g weight) were used. Animals were 
randomly assigned into saline-control (SC), saline-training (ST), and Baneh-control (BC), and Baneh-training 
(BT). Training groups were given exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 
min/dayand5 days/week for eight weeks. Subjects were fed orally, with Baneh extraction and saline for four 
weeks. ABCG1 relative gene expression was detected by Real-time PCR method.
Results: results demonstrated that Baneh extraction significantly reduces ABCG1relative gene expression in 
small intestine (P < 0.02). 
Discussion and Conclusion: exercise training increases ABCG1relativegeneexpressionin small intestine; 
therefore exercise training may adjust the reduction in Baneh exercise group.

Keywords

• ABCG1
• female rats
• Treadmill exercise
• ABC transporters
• Pistachio atlantica

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