The Role of Exercising and Curcumin on the Treatment of lead-induced Cardiotoxicity in Rats

Document Type : Original Article

Abstract

The present study aims to evaluate Cardioprotection effects of exercise training and curcumin on myocardial 
damage induced by lead acetate. Forty-eight rats were randomly divided into six groups of the base, sham, 
lead, exercise, curcumin and exercise+curcumin (EC). The rats in the exercise and (EC) groups performed the 
progressive treadmill running of 15 to 22 m/min for 25 to 64 min, 5 times a week for 8 weeks. Lead, exercise, 
curcumin and (EC) groups received lead acetate (20 mg/kg), and sham, curcumin and (EC) groups received 
curcumin solvent (ethyloleat) and curcumin solution (30 mg/kg). Cardiac tissue was removed of aorta hiratus 
and homogenized for the estimation of troponin I, using ELISA. CK-MB and lead was determined in serum by 
immunological DGKE method and atomic absorption Spectrophotometry methods, respectively. Injection of 
lead acetate into intra-peritoneal resulted in a significant increase of the CK-MB levels. However, treadmill 
running exercise and curcumin supplementation resulted in a significant decrease of CK-MB levels while there 
was no significant difference in troponin I levels. The results of this study suggest the cardioprotective 
potential of administration of exercise and curcumin in ameliorating the lead-induced cardiotoxicity in rats 
through a decrease of myocardial damage markers.

Keywords

• Aerobic training
• Antioxidant
• Pollution
• Cardiac damage
• Rat

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